BerandaComputers and TechnologyCovid-19 Herd Immunity Strategies Could Bring ‘Untold Death and Suffering’

Covid-19 Herd Immunity Strategies Could Bring ‘Untold Death and Suffering’

basic reproduction number, R0—the number of cases, on average, spawned by one infected individual in an otherwise fully susceptible, well-mixed population, says Kin On Kwok, an infectious-disease epidemiologist and mathematical modeller at the Chinese University of Hong Kong. The formula for calculating the herd-immunity threshold is 1–1/R0—meaning that the more people who become infected by each individual who has the virus, the higher the proportion of the population that needs to be immune to reach herd immunity. For instance, measles is extremely infectious, with an R0 typically between 12 and 18, which works out to a herd-immunity threshold of 92–94% of the population. For a virus that is less infectious (with a lower reproduction number), the threshold would be lower. The R0 assumes that everyone is susceptible to the virus, but that changes as the epidemic proceeds, because some people become infected and gain immunity. For that reason, a variation of R0 called the R effective (abbreviated Rt or Re) is sometimes used in these calculations, because it takes into consideration changes in susceptibility in the population.

Although plugging numbers into the formula spits out a theoretical number for herd immunity, in reality, it isn’t achieved at an exact point. Instead, it’s better to think of it as a gradient, says Gypsyamber D’Souza, an epidemiologist at Johns Hopkins University in Baltimore, Maryland. And because variables can change, including R0 and the number of people susceptible to a virus, herd immunity is not a steady state.

Even once herd immunity is attained across a population, it’s still possible to have large outbreaks, such as in areas where vaccination rates are low. “We’ve seen that play out in certain countries where misinformation about vaccine safety has spread,” Salathé says. “In local pockets, you start to see a drop in vaccinations, and then you can have local outbreaks which can be very large, even though you’ve technically reached herd immunity as per the math.” The ultimate goal is to prevent people from becoming unwell, rather than to attain a number in a model.

How high is the threshold for SARS-CoV-2?

Reaching herd immunity depends in part on what’s happening in the population. Calculations of the threshold are very sensitive to the values of R, Kwok says. In June, he and his colleagues published a letter to the editor in the Journal of Infection that demonstrates this. Kwok and his team estimated the Rt in more than 30 countries, using data on the daily number of new COVID-19 cases from March. They then used these values to calculate a threshold for herd immunity in each country’s population. The numbers ranged from as high as 85% in Bahrain, with its then-Rt of 6.64, to as low as 5.66% in Kuwait, where the Rt was 1.06. Kuwait’s low numbers reflected the fact that it was putting in place lots of measures to control the virus, such as establishing local curfews and banning commercial flights from many countries. If the country stopped those measures, Kwok says, the herd-immunity threshold would go up.

Herd-immunity calculations such as the ones in Kwok’s example are built on assumptions that might not reflect real life, says Samuel Scarpino, a network scientist who studies infectious disease at Northeastern University in Boston, Massachusetts. “Most of the herd-immunity calculations don’t have anything to say about behaviour at all. They assume there’s no interventions, no behavioural changes or anything like that,” he says. This means that if a transient change in people’s behaviour (such as physical distancing) drives the Rt down, then “as soon as that behaviour goes back to normal, the herd-immunity threshold will change.”

Estimates of the threshold for SARS-CoV-2 range from 10% to 70% or even more. But models that calculate numbers at the lower end of that range rely on assumptions about how people interact in social networks that might not hold true, Scarpino says. Low-end estimates imagine that people with many contacts will get infected first, and that because they have a large number of contacts, they will spread the virus to more people. As these ‘superspreaders’ gain immunity to the virus, the transmission chains among those who are still susceptible are greatly reduced. And “as a result of that, you very quickly get to the herd-immunity threshold”, Scarpino says. But if it turns out that anybody could become a superspreader, then “those assumptions that people are relying on to get the estimates down to around 20% or 30% are just not accurate”, Scarpino explains. The result is that the herd-immunity threshold will be closer to 60–70%, which is what most models show (see, for example, ref. 6).

Looking at known superspreader events in prisons and on cruise ships, it seems clear that COVID-19 spreads widely initially, before slowing down in a captive, unvaccinated population, Andersen says. At San Quentin State Prison in California, more than 60% of the population was ultimately infected before the outbreak was halted, so it wasn’t as if it magically stopped after 30% of people got the virus, Andersen says. “There’s no mysterious dark matter that protects people,” he says.

And although scientists can estimate herd-immunity thresholds, they won’t know the actual numbers in real time, says Caitlin Rivers, an epidemiologist at the Johns Hopkins Center for Health Security in Baltimore. Instead, herd immunity is something that can be observed with certainty only by analysing the data in retrospect, maybe as long as ten years afterwards, she says.

Will herd immunity work?

Many researchers say pursuing herd immunity is a bad idea. “Attempting to reach herd immunity via targeted infections is simply ludicrous,” Andersen says. “In the US, probably one to two million people would die.”

In Manaus, mortality rates during the first week of May soared to four-and-a-half times what they had been the preceding year. And despite the subsequent excitement over the August slowdown in cases, numbers seem to be rising again. This surge shows that speculation that the population in Manaus has reached herd immunity “just isn’t true”, Andersen says.

Deaths are only one part of the equation. Individuals who become ill with the disease can experience serious medical and financial consequences, and many people who have recovered from the virus report lingering health effects. More than 58,000 people were infected with SARS-CoV-2 in Manaus, so that translates to a lot of human suffering.

Earlier in the pandemic, media reports claimed that Sweden was pursuing a herd immunity strategy by essentially letting people live their lives as normal, but that idea is a “misunderstanding”, according to the country’s minister for health and social affairs, Lena Hallengren. Herd immunity “is a potential consequence of how the spread of the virus develops, in Sweden or in any other country”, she told Nature in a written statement, but it is “not a part of our strategy”. Sweden’s approach, she said, uses similar tools to most other countries: “Promoting social distancing, protecting vulnerable people, carrying out testing and contact tracing, and reinforcing our health system to cope with the pandemic.” Despite this, Sweden is hardly a model of success—statistics from Johns Hopkins University show the country has seen more than ten times the number of COVID-19 deaths per 100,000 people seen in neighbouring Norway (58.12 per 100,000, compared with 5.23 per 100,000 in Norway). Sweden’s case fatality rate, which is based on the number of known infections, is also at least three times those of Norway and nearby Denmark.

What else stands in the way of herd immunity?

The concept of achieving herd immunity through community spread of a pathogen rests on the unproven assumption that people who survive an infection will become immune. For SARS-CoV-2, some kind of functional immunity seems to follow infection, but “to understand the duration and effects of the immune response we have to follow people longitudinally, and it’s still early days”, Buckee says.

Nor is there yet a foolproof way to measure immunity to the virus, Rivers says. Researchers can test whether people have antibodies that are specific to SARS-CoV-2, but they still don’t know how long any immunity might last. Seasonal coronaviruses that cause common colds provoke a waning immunity that seems to last approximately a year, Buckee says. “It seems reasonable as a hypothesis to assume this one will be similar.”

In recent months, there have been reports of people being reinfected with SARS-CoV-2 after an initial infection, but how frequently these reinfections happen and whether they result in less serious illnesses remain open questions, says Andersen. “If the people who are infected become susceptible again in a year, then basically you’ll never reach herd immunity” through natural transmission, Rivers says.

“There’s no magic wand we can use here,” Andersen says. “We have to face reality—never before have we reached herd immunity via natural infection with a novel virus, and SARS-CoV-2 is unfortunately no different.” Vaccination is the only ethical path to herd immunity, he says. How many people will need to be vaccinated—and how often—will depend on many factors, including how effective the vaccine is and how long its protection lasts.

People are understandably tired and frustrated with imposed measures such as social distancing and shutdowns to control the spread of COVID-19, but until there is a vaccine, these are some of the best tools around. “It is not inevitable that we all have to get this infection,” D’Souza says. “There are a lot of reasons to be very hopeful. If we can continue risk-mitigation approaches until we have an effective vaccine, we can absolutely save lives.”

This article is reproduced with permission and was first published on October 21 2020.

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